video game does not load cd rom

I have a game that will not load on my computer. I don't belive it has had on my last computer wich vista, but not this one. There duke nukum 3 d on cd rom and it will play the music on the disc but not to load the game to play. no idea on what is happening, my other games cd load correctly. e:\Install.ex is all I get when I tryto play or load it.

You will need to install Duke nukem 3d with http://www.dosbox.com/

Here is the link the game discussions, use them for assistance if necessary.

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