My Mac won't let me click on some apps?

I have a MacBook Air with El Capitan 10.11.3

If this starts only today, but what happened is, it is that when I open microsoft word, PowerPoint, applications etc. I can't click on anything, I try to click on full screen, nothing, I try to click to close, nothing, just by clicking on anything that does not work, I have to force quit the application. But this happens not just with microsoft applications, it goes with the Messages (iMessage), the App Store app so I can't update the laptop so I can't verify if this is the problem, and that's all I know that it does not work so far. But it seems to work in Chrome and Spotify, and that's all that I know that the work so far. I tried the force quit applications and their reopening and stop my laptop and turn it back on but nothing works. If anyone knows whats wrong or how to fix that would be lovely.

Thank you.

Restart in safe mode

Try safe mode if your Mac does not end commissioning - Apple Support

then restart normally

If the problem persists after an etrecheck report for further analysis

www.etrecheck.com

Tags: Mac OS & System Software

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