Cannot install the files .exe or Windows updates, "you may not permissions appropriate to access them.

I completely downloaded from the internet does not run or install .exe files. I get this message: Windows cannot access the specified device, path or file. May not be the appropriate permissions for access you to them.

Also, I can't get updates to Windows, such as Windows Defender. And even if I manually downloaded updates, always I can't install them.
Help, please.

http://Windows.Microsoft.com/en-us/Windows-Vista/turn-user-account-control-on-or-off

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