How to manually or programmatically set the pointer speed to mouse to a value exceeding the threshold available in Control Panel?

I have a disability that limited my range of motion. The maximum setting in the control panel to the speed of the mouse pointer is not enough for me, especially on the horizontal axis. Is it possible to manually adjust this setting beyond what is available in the control panel? A registry setting? A call to the Windows API? Please notify.

In the registry, go to:

HKEY_CURRENT_USER\Control Panel\Mouse

Set the key: MouseSensitivity

Range of values set via the GUI is: 1 to 20

You can try to set the value above 20 (the highest speed set via the GUI).

I tried to change the values in the registry, however since the driver does not reload the values I don't know how do to cause the changes to take effect.

Since you mentioned the API call, here are a few discussions deep in to the mouclass.sys (file of class system, Microsoft HID-compliant mouse):
http://www.eggheadcafe.com/forumarchives/win32programmerkernel/Nov2005/post24565529.asp

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