Quit Safari is grayed out suddenly in menu - can't leave Safari except to quit Activity monitor

Safari 9.0.2 Mac OS X El Capitan 10.11.2

Quit suddenly started Safari appear grayed out in the menu on my iMac mid-2011 tonight. The only way I can leave Safari is to force quit the application in the activity monitor. Right click on the Safari icon in the dock and selecting exit does not work. This problem showed up today. Also this morning a new user of comments that I've created suddenly appeared on my screen, connection when I logged on my Mac. Previously I had disabled guest user. No one else has access to my computer. I have disabled guest user on my Mac again after that I logged. And then tonight, options to quit Safari have suddenly been disabled. Any ideas or suggestions?

Safari/Preferences/Advanced - activate the menu to develop it, then go ahead and empty Caches. Quit/relaunch Safari and test. Then try Safari/history/Show History and remove all items from the history.  Quit/relaunch Safari and test. You can also try try Safari/Clear History... The downside is that it deletes all cookies. It could upset some sites no longer recognizes your computer as one that has visited the web site. Go to Finder and select your user folder. With this Finder window as the windshield, select Finder/display/display options for presenting or order - J.  When the display options opens, check "show the library folder. This should make your visible user library folder in your user folder.  Select Library./Caches/com.apple.Safari/Caches.db, and then move it to the trash.

Go to Safari preferences/Extensions and disable all extensions. Test. If correct, enable the extensions one by one until find you which extension is causing the problem.

Corruption Safari       See post by Linc Davis

Tags: Mac OS & System Software

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