-Pop-up window that will not go away unless I Quit Safari

I have an iMac 24 inch running OS X El Capitan.  Since the upgrade to El Capitan, I had the following annoying popup ad which seems to appear whenever I open a new tab, do a google search, or click a link to a Web site.  I tried to clear my history and cookies, but nothing seems to work.  Does anyone know what I can try next?  I tried Malwarebytes Anti Malware which found nothing wrong.  I have installed Adbocker more.  Help!

Force Quit Safari (-> force quit-> Safari), then restart in Mode safe mode by pressing the SHIFT key.  This prevents any tabs/windows to reopen.

Tags: Mac OS & System Software

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